Supplements

11 best Lion's Mane supplements to improve focus & productivity

A deep dive into the magic of mushrooms.
Best Lion's Mane Supplements UK 2026
Getty Images/Collage: Condé Nast

Featured in this article

Best Lion's Mane supplement overall
Wild Nutrition Food-Grown Organic Protein + Superfood Powder
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The runner-up
Protein Works Lion's Mane Limitless
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Best vegan Lion's Mane supplement
KIKI Health Organic Lion's Mane Extract
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Disclaimer: Keep in mind that this article isn't a substitute for professional medical advice, and our recommendations won't replace a healthy lifestyle and balanced diet.


What is Lion's Mane, and what are the benefits?

“Lion’s Mane is a type of medicinal mushroom,” details women’s health nutritionist Stephanie Smith. “These are fungi with purported pharmaceutical benefits.” Another word for this type of mushroom is ‘functional,’ which dietitian nutritionist Lena Bakovic says has taken off in recent years.

“Their popularity has grown due in large part to the mushrooms’ purported adaptogenic properties,” she says. “Adaptogens, which have been a constituent of Eastern Medicine for many years, are thought to help counteract the effects of stress on our bodies.”

Recent studies suggest that Lion's Mane may help alleviate stress and improve focus or speed when completing tasks, but further research is needed on a larger scale. “The research on lion's mane is promising but still developing,” adds Doctify-rated nutritionist Raquel Britzke. “Some studies suggest benefits for memory and brain function, but we need more human trials. Some research also suggests gut microbiome benefits."


Ahead, the best Lion's Mane supplements for 2026, tried & tested by Glamour editors:


Lion's Mane FAQs, answered:

What is the best way to take Lion's Mane?

“To get the most out of your supplement, look for a fine powder form of lion’s mane,” says Bettervits’ Accredited Nutritionist and Head of Product, Harriet Hunter. “The particles will increase bioavailability within the body. Additionally, taking the supplement with or alongside a meal rich in healthy fats may help improve absorption”.

Wondering what time of day is best? Hunter adds that there is no single best time to take Lion’s Mane. “However, it is often recommended as part of a morning routine to help support its benefits throughout the day,” she adds.

Are there any side effects of taking Lion’s Mane supplements?

Lion's Mane supplements are considered to be ‘well-tolerated’ by most, meaning side effects are rare. However, Bakovic says there are a couple of key signs to watch for: "The side effects that have been reported are related to digestive upset, potentially allergic reactions, and skin rashes.”

“For most people, lion's mane is considered safe when consumed in food amounts or taken as a supplement from reputable sources," adds Doctify-rated nutritionist Raquel Britzke. “However, some individuals may experience mild digestive discomfort or allergic reactions. It may also interact with blood thinners or medications for diabetes due to its potential effects on blood clotting and glucose regulation.”

Who should and shouldn’t take Lion’s Mane?

“As with all supplements, there is not always a need to take them," stresses Smith. "However, if people are looking for help with focus, concentration, nervous system support or would like to supplement specifically for brain and cognitive health, then Lion’s Mane could be something of interest.”

In terms of who should avoid it, Bakovic notes that, “due to the limited amount of research supporting the benefits of these mushrooms at this time, and especially during pregnancy, it is advisable that pregnant women should avoid taking Lion's Mane mushrooms or supplements.”

“But before taking any supplement, it is recommended to discuss it first and foremost with a healthcare provider/physician to ensure that there are no potential dangers or drug/nutrient interactions.”


Meet the experts:

Lena BakovicRegistered dietitian nutritionist and author.
Stephanie SmithWomen’s health nutritionist speaking on behalf of women’s health platform, Agora Health.
Kyle CrowleyProtein Works' product director.
Raquel BritzkeDoctify-rated nutritionist with 15 years of experience.
Harriet HunterBettervits’ accredited nutritionist and head of product.