We tried every NAD+ supplement so you don't have to — here are our top-rated
The best NAD+ supplements have been buzzed about for years, famously used in IV form by A-list celebrities like Kendall Jenner and Hailey Bieber. But why the hype? Experts have praised it for boosting mental clarity and cognitive function, raising energy levels, and delaying signs of ageing.
Sadly, for mere mortals without a personal IV practitioner on hand, NAD was — until recently — an expensive and out-of-reach supplement. That was until it became more readily available in a capsule at a fraction of the price.
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But while NAD+ is becoming more commonplace in many people's supplement lineup, you may be wondering what on earth NAD+ actually is. Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme that serves two crucial roles: fuelling your cells’ energy production and supporting cellular defence. Our bodies naturally produce NAD+, but like many nutrients and hormones, our natural production declines as we age.
FYI, testing into NAD+ supplementation is still ongoing, and it goes without saying to check with your GP before heading to the checkout. But, for those craving a boost to their metabolic health and energy levels without the help of coffee or energy drinks, this might be the answer.
It’s important to note that some health experts, like dietitian and partner with Tru Niagen, Toby Amidor, believe that supplementing with the NAD+ molecule itself, whether by IV drip or with supplements, is ineffective in elevating NAD+ levels: “As a large molecule, NAD+ cannot pass through cell membranes and must first be broken down into its constituents.”
His advice if you do want to try dosing up? Take nicotinamide riboside (NR), a unique form of vitamin B3, not NAD+. “While there are natural food sources of vitamin B3, such as milk, salmon, peanuts, and avocados, you’d need to consume about 87 gallons of milk daily to get 300 mg of NR."
But for those keen to test the potential benefits for themselves, below are the best NAD+ supplements approved by registered dieticians and Glamour editors who have spent the last seven months personally trialling a host.
Read on for our honest thoughts, as well as answers to common supplement FAQs.
How we test the best NAD+ supplements:
Since March 2025, the Glamour team has trialled countless NAD+ supplements — as well as sleep supplements, vitamin D supplements and collagen supplements — in a bid to only recommend the very best. We've tested one formulation each for a minimum of six weeks, making sure that everyone who participated in the reviewing process varied in terms of age, skin type and hair type.
At the end of their trial period, they were asked to rate it against the following criteria:
- Ease of use — Were the capsules easy to swallow? Did the powder mix well with water?
- Efficacy — How long into the four weeks did they notice a difference, if any?
- Taste — On a scale of one to five, how pleasurable was the taste?
- Value for money — Would they be happy to commit to the weekly, monthly or bi-monthly spend?
Why you can trust me: Freelance contributor, Cat Hufton
I'm an experienced lifestyle journalist who has tested hundreds of products in my quest to find the best products worthy of your hard-earned money. I became particularly interested in wellness and health products after having children seven years ago, and I needed a little extra helping hand in feeling my best. Finding supplements to help me manage the everyday stresses of work and family life has also become a personal passion project of mine.
As such, I've spoken to countless industry experts, tested a wide variety of supplements and wellness products, and become pretty astute at knowing what really makes a difference.
Disclaimer: Keep in mind that this article isn't a substitute for professional medical advice, and our recommendations won't replace a healthy lifestyle and balanced diet.
Ahead, the best NAD+ supplements for 2026, according to Glamour editors and experts:
Type: Capsule.
Dose: Two capsules.Designed specifically with promoting longevity in mind, these impressive supplements contain a beautifully balanced formula of key ingredients — all of which help combat cellular ageing, and protect us from disease in the long run. A powerful polyphenol and antioxidant, resveratrol works alongside NR to increase NAD+ levels — leading to improved DNA repair and cellular energy production. Meanwhile, the flavonoid luteolin helps to support the recycling of NAD+ in our bodies. A great all-round health supplement for boosting your overall well-being, each pill is also enriched with a blend of phytonutrients and plant extracts to support your overall well-being — like saffron, ginseng, and pine bark extract.
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Pros & ConsPros- B-Corp brand.
- Contains targeted phytonutrients.
- Handy subscription service.
Cons- May interact with other medications.
Type: Capsule.
Dose: One capsule.Designed to support energy, longevity, and cellular health, the designers of these NAD+ supplements used innovative SAIFx technology to develop the world’s first truly dry liposomes for nutraceuticals. In non-medical speak, the nutrients. They claim these exceptionally small liposomes easily penetrate cellular barriers and enter the bloodstream, making this one of the most effective NAD+ capsules on the market, RN.
Our testers confirmed that, after a month of taking these supplements daily, they had noticed a boost in their energy levels, reporting less morning grogginess and brain fog. They also commented on the medium size of the capsules, confirming they were easy to swallow and left no unpleasant aftertaste.
Pros & ConsPros- They've kept it simple, with these supplements only containing four ingredients.
- Pioneered by a Professor of Pharmaceutics & Nanomedicine with over 20 years’ experience.
- A more accessible version of the brand's highly-rated injectable NAD+ supplement.
Cons- Expensive — a 90-day supply will cost you £169, even with 25% off.
Type: Capsule
Dosage: 300mgThis NAD+ supplement comes backed by 1,000 scientific studies, and combines 300mg of NAD+ precursor with CoQ10 to support cellular energy and vitality. There's also 250mg of trans-resveratrol in each daily dosage to protect the body against ageing. This makes it ideal for anyone wanting better, sustained energy throughout the day along with a clearer mind, and a generally more resilient body. It's also plant-based, vegan and gluten-free.
Pros & ConsPros- Vegan and cruelty free.
- There's a 300mg dose of NAD⁺ precursor in just one daily capsule.
Cons- This is an expensive supplement option.
Type: Patch.
Dose: One patch per day.We're sure you've seen Kind's patches all over your FYP, the various types praised for delivering boosts of energy, relieving period pains and aiding sleep. However, the brand's NAD+ packed patches have been designed to address signs of ageing. Infused are both Resveratrol, which visibly diminishes fine lines and enhances the look of elasticity, as well as N-acetylcysteine (NAC), which protects against environmental aggressors that can contribute to premature skin ageing
How do they work? Each day, stick one to your wrist, upper arm, shoulder or back and wear it for up to eight hours. Arguably, they were the easiest supplements in our lineup to incorporate into my daily routine — I kept them next to my daily moisturiser as a visual reminder to apply one. While it took a while to see visible results, I have no complaints about the wear or value.
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Pros & ConsPros- Works out at just 40p a patch.
- Easy to use and wear, with no signs of irritation (even on sensitive skin).
- 100% vegan.
Cons- You'll have to avoid applying lotions or creams to the area to guarentee effective absorption.
Type: Capsule.
Dose: 1,000 mg.If you’ve been taking NAD and want to bump up the dosage, try Tru Niagen Pro 1000 mg. It contains the same patented form of NR and is NSF Certified for Sport, meaning it’s been lab-tested and contains all the ingredients that are on the label. One serving is two capsules, which contain 500 mg each, so you’re getting 1,000 mg of NR—the recommended higher dosage. This dosage may be especially helpful for older adults. “Individuals over the age of 50 tend to have higher needs of NAD due to reduced liver recycling of NAD, and they could benefit from higher doses of NR,” says Dr Raj Singh, an internal medicine doctor with years of experience working with NAD. If you don’t want to start out with a high dosage, you can try their beginner-friendly Tru Niagen 300 mg.
“I took one 300 mg capsule for two weeks and then bumped it up to two capsules for a total of 600 mg for another two weeks—and since, I’ve noticed my energy levels feel naturally higher. I don’t feel a jolt, per se; it’s more like a steady wakeful feeling. And I don’t feel so reliant on my morning coffee anymore,” says Glamour contributor April Benshosan.
Pros & ConsPros- Clinically effective dose.
- Tested for purity and potency.
Cons- Relatively pricey.
Type: Capsule
Dosage: 300mgIf fatigue and maintaining good energy is something you struggle with, the methylated B vitamins in this supplement along with 300mg of nicotinamide riboside, a direct NAD+ precursor, will give you a much needed boost. There's also added vitamin D3 and vitamin K2 which contribute to the maintenance of normal bones and the normal absorption and utilisation of calcium. In short, it helps to benefit your overall health and wellbeing including metabolism and psychological function.
Pros & ConsPros- Contains added methylated B vitamins and plant-based extracts.
- Made in the UK and third-party tested.
Cons- Two capsules are needed to get a 300mg dose of NAD precursors.
Life Extension NAD+ Cell Regenerator and Resveratrol Elite
Type: Capsule.
Dose: 300 mg.Life Extension’s NAD+ Cell Regenerator and Resveratrol Elite contain Niagen, the same type of patented NR in Tru Niagen. It also packs in a moderate 300 mg dose of NR, which is suitable if you’re new to taking it.
“Since NAD supplements may trigger side effects like nausea and heart palpitations, starting with a conservative 300 mg dose before gradually increasing is recommended,” says Singh. This supplement also contains added antioxidants, including resveratrol, quercetin and fisetin, which are natural compounds found in plant foods (like fruits, veggies, and tea) that have been shown to possess anti-ageing properties, promoting longevity and overall health, says dietitian Lauren Manaker.
Some research shows that resveratrol and quercetin can work synergistically with NR, potentially boosting its effects. However, quercetin and resveratrol can interact with many prescription medications – so if you’re on any meds, make sure to check with your doctor before taking this supplement. This supplement is non-GMO, third-party-tested, and vegetarian-friendly.
Pros & ConsPros- Contains added antioxidants.
- Suitable dosage for beginners.
- Third-party-tested.
Cons- May interact with certain medications.
Type: Capsule.
Dose: 415 mg.Thorne’s ResveraCel supplement contains 415 mg of NR along with quercetin and resveratrol to help support healthy ageing. “Quercetin phytosome is a compound that has been researched for its potential to reduce cellular senescence (when cells stop dividing and remain in the body, causing inflammation, rather than dying off),” Manaker says.
“Quercetin works synergistically with resveratrol in promoting healthy ageing by slowing down the breakdown of resveratrol within the body, allowing it more time to exert its effects.” But since quercetin and resveratrol interact with many prescription medications, make sure to check with your doctor before taking this supplement. In addition to these antioxidants, it also contains betaine — an amino acid that has been shown to help increase muscle endurance.
Pros & ConsPros- With added antioxidants.
- Third-party-tested.
Cons- May interact with certain medications.
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Type: Capsule.
Dose: 500 mg.ProHealth’s NAD Triple Boost provides not only 500 mg of Niagen NR but also B vitamins and antioxidants. You’ll get over 100% of your daily value of vitamins B2, B3, B6, and B12, which are all essential in energy production. This supplement also contains quercetin and apigenin, which have anti-inflammatory effects and work synergistically to promote healthy NAD levels, according to some studies. Plus, it packs the antioxidant PQQ, which supports mitochondrial function and heart health, as well as ginseng, which supports cognitive function, Manaker says.
Pros & ConsPros- Contains added B vitamins and antioxidants.
- Similar to a multivitamin.
- Third-party-tested.
Cons- Relatively expensive.
NAD+ supplements FAQs, answered:
What are the benefits of NAD+ supplements?
NAD+ plays a role in energy production and cellular repair to support the ageing process. While more research needs to be done to understand the long-term effects of NAD+ supplements, below are some findings from current studies on its benefits.
- Lower inflammation: Research shows that boosting NAD with supplements like NR may help reduce inflammation, especially in older adults or people with inflammatory conditions.
- Brain health: Some research suggests that supplementing with NR can help with age-related cognitive decline, but more studies are needed to solidify these findings. Research shows that supplementing with NR increases levels of NAD in the brain, and a small study gave 30 people with Parkinson’s disease (a brain disorder) 1,000 mg of NR or a placebo for 30 days and found that those who took the NR had less inflammation in the blood and brain.
- Muscle health and recovery: Your skeletal muscles are rife with mitochondria, and they need NAD+ to make energy for movement. NAD+ helps your muscles generate ATP, the fuel for contractions. “Your cells also need to repair themselves from any damage, and cellular repair requires NAD+,” Amidor says.
- Fertility: Most of the research around NR and fertility is preclinical, meaning studies are conducted in the early stages, typically in labs using cells or animal models. But the data is promising and suggests that elevating NAD+ may support ovarian cell health, Amidor says.
What is the best form of NAD+ to take?
Nicotinamide Mononucleotide (NMN) is a NAD+ precursor that has shown promise in animal studies — but the most efficient and effective way to elevate NAD+ is with the precursor nicotinamide riboside (NR), which is a unique form of vitamin B3 (niacin).
“Unlike the NAD+ molecule itself, NR is the most efficient because it crosses the cell wall directly and requires fewer steps to convert into NAD+,” says Amidor. Finding the best dosage depends on different factors like age and your overall health. “People experiencing digestive absorption challenges and inflammatory conditions typically need elevated doses, as their bodies struggle with absorption while consuming more NAD,” Dr Singh says.
Since NAD is regenerated in the liver, people who drink too much alcohol, take medications like acetaminophen (Tylenol), or have liver issues often have lower NAD levels. They can benefit from higher oral NAD supplementation.
Are there any risks or side effects associated with NAD+?
NR is the only NAD+ booster that has no known interactions or adverse effects. Other B3 precursors, such as nicotinic acid (NA) and nicotinamide, do have side effects. At high doses, NA causes intense flushing, and nicotinamide may cause GI issues.
“Oral NR supplementation is the most well studied form of NAD+ and is well tolerated up to one gram per day,” explains ARTAH founder, nutritionist and naturopath, Rhian Stephenson. “Like most supplements, safety concerns come into play when people decide to mega dose, so it's always best to ere on the side of caution and not exceed recommended dosing.”
Stephenson adds that NAD+ IV's have the risk — like any IV — of IV site pain, phlebitis, infection risk, vasovagal reactions etc. “So if you are getting NAD+ infusions, make sure you feel comfortable with the clinic's hygiene and safety procedures."
In short, NR supplements are generally well-tolerated, but that doesn’t mean they’re safe for everyone. People with pre-existing cardiac rhythm disorders, particularly atrial fibrillation or other arrhythmias, should check with their doctor before taking NR due to potential heart palpitations. What’s more, NR supplements haven’t been studied in people with cancer or in women who are pregnant or breastfeeding. If you fall into any of these camps, check with your doctor before starting an NR supplement.
Meet the experts:
| Toby Amidor | Dietitian and partner with Tru Niagen. |
| Dr Raj Singh | Internal medicine doctor with years of experience working with NAD+. |
| Lauren Manaker | Dietitian. |
| Rhian Stephenson | ARTAH founder, Nutritionist and Naturopath. |
