8 best peptide serums I've tested, backed by dermatologists
Ask any dermatologist, and they’ll tell you that peptides are one of the smartest ingredients you can add to your skincare routine. No wonder peptide serums have earned holy grail status among beauty obsessives – with searches rising by 350 per cent on Google in the last month alone.
“Peptides are chains of amino acids that act as the building blocks of essential proteins like collagen, elastin and keratin,” explains Dr Sonia Khorana, a cosmetic doctor and dermatology expert. “These proteins play a key role in maintaining the skin’s texture, tone, elasticity and firmness.”
She adds, “When peptides are delivered in a serum, they essentially signal the skin to begin repairing itself. This prompts increased collagen production, helping to restore a healthier, more radiant-looking complexion.” Gentle yet effective, they sit neatly alongside other hard-working actives - from the brightening power of the best vitamin C serums to the moisture-boosting benefits of the best hyaluronic acid serums.
Best of all, peptide serums are non-irritating by nature, making them suitable for all skin types, ages and concerns. With regular use, Dr Khorana notes that you can expect “visible improvements in wrinkles, a stronger skin barrier, reduced inflammation and enhanced hydration.” Ahead, I've curated the ultimate edit of the best options that myself and my colleagues have spent months testing – all dermatologist-approved. Ready to elevate your skincare routine? Let’s get into it.
My favourite peptide serums, at a glance:
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- Meet the experts
- Shop our full edit of tried and tested peptide serums
- How I tested the best peptide serums
- Which peptide serum impressed us most? GLAMOUR's top pick
- What are the different types of peptides?
- Do peptide serums actually work?
- What other skincare ingredients pair well with peptides?
- What should I not mix peptides with?
Meet the experts:
| Dr. Zeichner | Associate Professor of Dermatology and the Director of Cosmetic & Clinical Research in Dermatology at Mount Sinai Hospital in New York. |
| Dr Sonia Khorana | Cosmetic doctor and dermatology expert. |
| Tiffany Libby, MD | Board-certified dermatologist in NYC. |
| Dr. Castilla | Board-certified dermatologist. |
| Daniel Isaacs | Director of research at Medik8 |
How I tested the best peptide serums:
I have relatively dry skin, so I’m always looking for hydrating serums that do more than simply sit nicely under moisturiser. I want formulas that feel comfortable, layer well and leave my complexion looking plumper, smoother and more hydrated – without adding unnecessary faff to my routine. When testing the best peptide serums, I started by calling a selection of the most popular products – as well as new launches – into the office. Then, I split them among the Glamour team – skin type dependent. We each paid close attention to texture, absorption, irritation, how well each formula worked under foundation and whether our skin looked healthier with consistent use.
Over four to six weeks, we tested the serums across a range of skin types, ages and concerns. Personally, I looked for formulas that helped soften the look of dryness and fine lines, supported my skin barrier and gave my complexion that bouncier, more refreshed appearance peptides are known for. Anything that felt sticky, pilled under sunscreen or makeup, caused irritation for more than one editor, or failed to deliver noticeable benefits didn’t make the final cut.
Which peptide serum impressed us most? Glamour's top pick:
After testing dozens of peptide serums, we concluded that there was one formula that ended up performing best on most skin types: the Medik8 Liquid Peptides Advanced MP.
We were particularly impressed with its breakthrough technology, which helps deliver results in as little as ten minutes and reduces deep-set wrinkles in under eight weeks.
The impressive serum uses mini-proteins to help relax and smooth out expression lines by supporting collagen and elastin production, all while boosting your skin's natural hydration levels.
The result? Plump, soft and glowy skin with visibly reduced fine lines and wrinkles. Chef's kiss.
Ahead, our full edit of tried and tested peptide serums.
1. Best Overall: Medik8 Liquid Peptides Advanced MP
- Tested by: Denise Primbet, Glamour's Freelance Beauty Contributor.
- Key Ingredients: Dual mini protein technology, 30% multi-peptide
- Skin Types: All, particularly mature skin.
- What we like: Visibly smooths out fine lines and wrinkles, feels incredibly hydrating on the skin.
- What could improve: Requires consistent use, often for 8 weeks or more to show results.
Why we love it: “Medik8’s Liquid Peptides Advanced MP is one of those serums I really wanted to put to the test, especially given its claims around a ‘filler-like effect.’ The formula uses two types of ‘mini’ proteins to help support collagen and elastin production, while also keeping skin feeling nicely hydrated.
"Texture-wise, it has a gel-like consistency that spreads easily and feels instantly smoothing on the skin. I did find it can feel a little sticky at first, but once it settles, that tackiness actually makes it work brilliantly as a primer under make-up. Over time, my skin looked a little plumper and more refreshed, and it’s also been proven to reduce the appearance of deep-set wrinkles in as little as eight weeks.”
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2. Best Korean: COSRX The 6 Peptide Skin Booster Serum
- Tested by: Shani Cohen, Glamour's Beauty Commerce Writer.
- Key Ingredients: Copper peptide, glycerin, peptide complex, bakuchiol, pumpkin and sunflower Skin Types: All.
- What we like: Absorbs quickly and seamlessly, plumps and hydrates skin, visibly firms.
- What could improve: May feel too greasy for oilier skin types.
Why we love it: "I’m a huge fan of COSRX in general – their Snail Mucin Essence is already a staple in my routine most days (yes, it sounds weird, but don’t knock it til’ you’ve tried it). As I have relatively dry skin, I’m always looking for something to boost hydration – and that’s where the 6 Peptide Skin Booster Serum comes in.
"Texture-wise it’s super lightweight and watery, but it gives skin that fresh, glowy finish without feeling super heavy which I always appreciate. It does stay slightly sticky - even once it dries down, but that makes it great for wearing under makeup. It’s formulated with six different peptides to help target firmness, fine lines and texture alongside niacinamide for brightness and hyaluronic acid and allantoin to keep skin hydrated and comfortable. I also like the large bottle, so I can imagine it lasting me ages – especially as a little goes a long way.
“One thing I will say: the serum comes out fast. The pump applicator is interesting and easy to use, but I’d definitely recommend pumping it into your hands first rather than directly onto your face unless you want it running down your cheeks and ruining your top. Other than that, it’s a Korean skincare staple I really rate easy to use, instantly hydrating and exactly what I reach for when my skin’s looking a bit flat. Shop more of the best Korean serums I love here.”
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3. Best PDRN: medicube PDRN Pink Peptide Serum
- Tested by: Denise Primbet, Glamour's Freelance Beauty Contributor.
- Key Ingredients: Peptide complex, ocimum tenuiflorum, hyaluronic acid and salmon collagen complex.
- Skin Types: All skin types.
- What we like: Has a nourishing yet a non-sticky feel, delivers intense hydration, helps strengthen the skin barrier.
- What could improve: Nothing of note.
Why we love it: “Coming from one of my favourite K-Beauty brands off all time, the medicube PDRN Pink Peptide Serum has been an absolute staple in my routine for months now. My rosacea-prone skin feels instantly soothed upon applying, and its nourishing texture helps keep my dry patches at bay. Above all, I love that the added benefits of PDRN help heal my PCOS-related breakouts with ease, further re-enforcing my skin barrier and ensuring lasting hydration,” shares Denise Primbet, Glamour's Freelance Beauty Contributor.
Working to help firm the skin and smooth out skin texture, this formula is filled to the brim with a whole host of skincare ingredients, including five types of peptides, ocimum tenuiflorum, hyaluronic acid and salmon collagen complex with coenzyme Q10 for an instant calming and moisturising effect.
4. Best Affordable: Nip + Fab Peptide Fix Finishing Oil 2%
- Tested by: Shani Cohen, Glamour's Beauty Commerce Writer.
- Key Ingredients: Copper peptide, glycerin, peptide complex, bakuchiol, pumpkin and sunflower Skin Types: All.
- What we like: Absorbs quickly and seamlessly, plumps and hydrates skin, visibly firms.
- What could improve: May feel too greasy for oilier skin types.
Why we love it: “There's a lot to love about this peptide serum by Nip + Fab. For starters, it's essentially two highly concentrated formulas in one - simply shake the bottle to combine the multi-peptides and nourishing oils with the active copper peptides. When activated, the peptides work together to stimulate the production of collagen and, therefore, encourage a firmer, smoother, and more hydrated complexion. Meanwhile, key skin-perfecting actives like refining and renewing bakuchiol, antioxidant-rich grapeseed oil, and moisturising baobab oil help to rejuvenate your appearance and leave you with a lit-from-within glow. Clinically proven to reduce the visibility of wrinkles by up to 45.79% in 4 weeks, it's basically an essential last step in any skincare routine.”
5. Best Glow: Rhode Peptide Glazing Fluid
- Tested by: Shani Cohen, Glamour's Beauty Commerce Writer.
- Key Ingredients: Copper peptide, glycerin, peptide complex, bakuchiol, pumpkin and sunflower Skin Types: All.
- What we like: Lightweight, easily absorbs and works well under makeup.
- What could improve: May be too lightweight for dry skin types.
Why we love it: “I used three pumps of the Peptide Glazing Fluid and totally get why people call it the secret to that ‘glazed donut’ glow. The serum-gel texture feels cool and light, sinking straight in and leaving my skin looking fresh and dewy without feeling sticky. It really helps smooth out any dryness and gives that healthy, glassy glow that makes your skin look alive. I even tried a bit over my makeup as a highlighter, and it gave me the ultimate Hailey Bieber shine – such a great multitasker."
6. Best Skin-Smoothing Formula: Naturium Multi-Peptide Advanced Serum
Tested by: Georgia Trodd, Glamour's Senior Commerce Writer.
Key Ingredients: Bargireline amplified peptide, ferulic acid and glycolic and lactic acid
Skin Types: All.
What we like: Absorbs easily, has a hydrating feel.
What could improve: Some of our testers found it lead to breakouts.
Why we love it: According to consultant dermatologist Dr Derrick Phillips, this serum from Naturium doesn't compromise on quality. "It contains Argireline amplified peptide to promote smoothness and elasticity of the skin, a combination of glycolic and lactic acid to improve skin texture, and ferulic acid to protect against the harmful effects of environmental free radicals that accelerate skin ageing. This readily absorbed serum can be easily incorporated into your routine after cleansing, and before applying your moisturiser,” he shares.
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7. Best Anti-Ageing: Allies of Skin Multi Peptides & GF Advanced Lifting Serum
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- Tested by: Shani Cohen, Glamour’s Beauty Commerce Writer.
- Key Ingredients: 3% sh-Oligopeptide-1, Lifting Peptide Complex, Copper Lysinate/Prolinate.
- Skin Types: All skin types.
- What we like: Great for lifting and fading fine lines. Also great for layering with other skincare products.
- What could improve: It's expensive.
Why we love it: “Allies of Skin is a brand I introduced into my routine last year, and I feel like its formulas are always one step ahead – from the Tripeptide & Ectoin Advanced Repair Serum to the Azelaic & Kojic Advanced Clarifying Serum.
"Now, I’m 30, so I wouldn’t say anti-ageing is a huge focus for me just yet, but I’m always open to trying something that promises to lift and firm. Unlike other anti-ageing serums I’ve tested which often take a while to show results, I noticed a difference in my skin after using this serum twice a day for one week.
"Texture-wise, it’s a lightweight, watery serum that absorbs into the skin within seconds, as you can see in my video. It doesn’t contain added artificial fragrance, which my sensitive skin always appreciates, though it does have a very light natural botanical, almost medicinal scent from its raw ingredients.
"I would say it feels a little sticky on the skin, even once dry, but it wears well under makeup and layers nicely with the rest of my routine, including vitamin C serum, moisturiser, and, of course, SPF. I also love applying it to my neck and décolletage, where I’ve noticed signs of ageing the most.”
8. Best For Mature Skin: SkinCeuticals P-Tiox Neuro-Peptide Serum
- Tested by: Denise Primbet, Glamour's Freelance Beauty Contributor. Note that we are working to test this product on more mature skin types, too.
- Key Ingredients: Advanced TFC8 technology, phyto-peptidic concentrate, biomimetic elastin
- Skin Types: All, particularly mature skin.
- What we like: The texture feels super silky and luxurious upon application, helps deliver visible results thanks to its advanced formula.
- What could improve: Some users with, or prone to, oily skin have reported breakouts.
Why we love it: "A brilliant pick for mature skin, this clever formula from SkinCeuticals is nothing short of impressive. Featuring an incredibly weightless feel, the P-Tiox Neuro-Peptide Serum has been especially formulated to help smooth out fine lines and texture, all while leaving your skin glowier than ever. It's infused with the brand's advanced peptide complex, niacinamide and laminaria to hydrate and even out skin tone, as well as 5% PHA for gentle exfoliation. The result? A glass-like glow and a visibly smoother complexion.
Shani Cohen, Glamour’s Beauty Commerce Writer, is also a huge fan of this serum. She says: “After using this consistently for a few months, I’ve noticed a visible difference in my skin texture and tone. My complexion looks brighter, more refined and a lot more balanced - especially around areas where I tend to get redness or pigmentation. It gives that subtle glass-skin effect without irritating my sensitive skin. When someone asks what serum I recommend - it’s always this one!”
FAQ's
What are the different types of peptides?
Most formulas feature a combination of peptides, so you don’t necessarily need to worry about how each functions, but it is worth familiarising yourself with the different types of peptides when looking at ingredients.
Signal peptides, like Matrixyl 3000, work by sending a message to the cells to boost production of proteins like collagen and elastin, which ultimately helps firm the skin. These are the most commonly used peptides in skincare. There’s also neurotransmitter cells like argireline, which Dr. Zeichner says help relax muscles and improve the appearance of wrinkles, smoothing the skin.
Meanwhile, he says carrier peptides (which include copper peptides) help to strengthen the barrier and stimulate collagen by delivering minerals to the skin. They function similarly to signal peptides in that they improve skin firmness and soften texture. Finally, there’s growth factor peptides to help with wound healing and skin regeneration. They also encourage collagen production (noticing a theme here?), making them particularly adept at reducing the appearance of fine lines.
Do peptide serums actually work?
With regular use, peptide serums are a worthy investment. “Peptides serums can help promote collagen synthesis which improves skin texture, reduces the appearance of wrinkles, and enhances skin tone,” Tiffany Libby, MD, a board-certified dermatologist in NYC, explains. Think of peptides as tiny little messengers that send signals to other cells to produce more collagen and elastin.
“Peptides also have hygroscopic properties, meaning they can attract and retain water, which helps hydrate skin and improve moisture retention.” That means peptides not only help immediately quench thirsty skin, but they also help the skin hold onto that moisture for longer.Peptides also help with overall skin repair and strengthen the skin barrier, which Dr. Engelman, a board-certified dermatologist says can help reduce moisture loss and contribute to healthier, more radiant skin. But, like any other product, those effects only work with regular continued use.
TLDR: Peptides help strengthen your skin by sending signals to other cells, while they work to improve hydration by drawing in and retaining water. All of this ultimately helps skin be more resilient and appear more radiant.
What other skincare ingredients pair well with peptides?
According to Dr. Zeichner, peptides generally play nice with other ingredients and skin care products. While Dr. Castilla, a board-certified dermatologist, says they tend to work best as part of a well-rounded skincare routine that includes daily face sunscreen and an antioxidant like one of the best vitamin C serums. Dr. Engelman also suggests pairing peptides with ingredients that help enhance their benefits, like vitamin C, niacinamide, and the best hyaluronic acid serum formulations.
She also recommends layering a peptide serum with a good face moisturiser that has ceramides in it to help lock in moisture and hydration, and strengthen the skin barrier. That being said, the dermatologists we spoke to warned against mixing peptides with harsh exfoliants like AHAs and BHAs, which may counteract the benefits of peptides. You can, however, pair peptides with retinol – in fact, they can help mitigate some of the irritation that comes with retinol use.
What should I not mix peptides with?
According to Daniel Isaacs, co-founder and chief product officer at Medik8, copper peptides should replace your vitamin C serum, as the two actives aren’t compatible and can cancel each other out. They’re also best avoided alongside high-strength AHAs (such as glycolic or lactic acid) and BHAs like salicylic acid. Benzoyl peroxide can also oxidise peptides, making them less effective and potentially irritating when layered together.
For more skincare-related content, shop our edit of the best hydrating serums for dry skin, ceramide serums to boost your delicate skin barrier, and the best retinol serums to elevate your nighttime routine.
